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-synuclein, and that is a most important component of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, that is an E3 ubiquitin ligase and brings about endoplasmic reticulum (ER) worry, propose that dysfunction with the intracellular proteinase methods, which include ubiquitin-proteasome technique or lysosomal process, which eliminates n
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Figure 1 Synthesis and degradation of ACh. ACh is synthesized from Acetyl-S-CoA and choline from the choline acetyltransferase (ChAT) enzyme inside the cytoplasm. ACh is secreted out quickly immediately after synthesis in non-immune cells but stored in a very specialised vesicle in neuronal cells secreted at presynaptic neurons immediately after ac
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